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Assessment of Diastolic Function Using 16-Frame 99mTc-Sestamibi Gated Myocardial Perfusion SPECT: Normal Values

Cigdem Akincioglu, MD1, Daniel S. Berman, MD1,2, Hidetaka Nishina, MD1, Paul B. Kavanagh, PhD1, Piotr J. Slomka, PhD1,2, Aiden Abidov, MD1, Sean Hayes, MD1, John D. Friedman, MD1,2 and Guido Germano, PhD1,2

1 Department of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, California
2 David Geffen School of Medicine at UCLA, Los Angeles, California



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  		FIGURE 1. Example of a patient’s volume and filling curves over time in 16-frame gated MPS. Numbers in brackets represent exact frame numbers from which parameters are derived. Arrow shows TTPF, defined by time from ES to greatest filling rate in early diastole. Peak filling is normalized to EDV. ED = end diastole; ES = end systole; BPM = beats per minute HR; MFR/3 = mean filling rate over first third of diastole.

 


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  		FIGURE 2. Scatter plots of relationship between PFR and HR (A) and TTPF and HR (B). Dotted line indicates 2-SD threshold. Solid line is regression line. In A, correlation coefficient (r) is 0.514, P = 0.01. In B, TTPF shows no correlation with HR.

 


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  		FIGURE 3. Scatter plots of relationship between PFR and EF (%) (A) and TTPF and EF (%) (B). Dotted line indicates 2-SD threshold. Solid line is regression line. In A, correlation coefficient (r) is 0.529, P = 0.01. In B, TTPF shows no correlation with EF (%).

 


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  		FIGURE 4. Scatter plots of relationship between PFR and age (A) and TTPF and age (B). Dotted line indicates 2-SD threshold. Solid line is regression line. In A, correlation coefficient (r) is –0.348, P = 0.01. In B, TTPF shows no correlation with age.

 




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