JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Namdar, M.
Right arrow Articles by Kaufmann, P. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Namdar, M.
Right arrow Articles by Kaufmann, P. A.

Integrated PET/CT for the Assessment of Coronary Artery Disease: A Feasibility Study

Mehdi Namdar, MD1, Thomas F. Hany, MD2, Pascal Koepfli, MD1, Patrick T. Siegrist, MD1, Cyrill Burger, PhD2, Christophe A. Wyss, MD1, Thomas F. Luscher, MD1, Gustav K. von Schulthess, MD, PhD2 and Philipp A. Kaufmann, MD1

1 Nuclear Cardiology Section, Division of Cardiology, University Hospital, Zurich, Switzerland
2 Division of Nuclear Medicine, University Hospital, Zurich, Switzerland



View larger version (65K):

[in a new window]
  		FIGURE 1. Three-dimensional reconstruction of multislice spiral CT scan showing coronary artery tree and shape of heart, superimposed by color-coded qualitative stress perfusion image obtained by PET. Ammonia has been used as perfusion tracer; red indicates normal stress perfusion response in anterior and lateral segments of left ventricle.

 


View larger version (48K):

[in a new window]
  		FIGURE 2. (A) Contrast-enhanced CT angiogram showing stenotic lesion in left circumflex coronary artery with faint poststenotic flow (arrow). (B) Coronary angiogram showing same stenotic lesion (arrow). (C) Combined 3-dimensional reconstruction of multislice spiral CT scan showing coronary artery tree and shape of heart, superimposed by color-coded qualitative stress perfusion image obtained by PET. Blue indicates reversible perfusion defect (i.e., ischemia). Lesion described in A and B is hemodynamically relevant, as documented by reduced hyperemic response to adenosine stress in lateral wall (arrowheads).

 


View larger version (11K):

[in a new window]
  		FIGURE 3. Overview of morphologic findings (angiography and CT) and functional findings (PET). For all territories subtended by normal or stenotic coronary vessels, categoric information on ischemia as assessed by PET is given.

 


View larger version (13K):

[in a new window]
  		FIGURE 4. Diagnostic algorithm for clinical decision making. Only the combination of angiographically significant stenosis and evidence of ischemia (by PET) led the decision toward revascularization. Angio = angiography.

 


View larger version (11K):

[in a new window]
  		FIGURE 5. Clinical decision making according to findings of PET plus angiography (Angio) represents gold standard. Decisions made according to PET/CT findings were compared with gold standard. NPV = negative predictive value; PPV = positive predictive value.

 




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 2005 by the Society of Nuclear Medicine.