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Accurate Dosimetry in ¹³¹I Radionuclide Therapy Using Patient-Specific, 3-Dimensional Methods for SPECT Reconstruction and Absorbed Dose Calculation

¹ Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical Center, Ann Arbor, Michigan
² Department of Medical Radiation Physics, University of Lund, Lund, Sweden
³ Pfizer Global Research and Development, Ann Arbor, Michigan
⁴ Division of Hematology and Oncology, Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, Michigan

View larger version (43K): [in a new window]   FIGURE 1. Two typical slices of voxel phantom show superimposed tumors. (A) Defined activity map. (B) Defined density map. (C) SPECT image. (D) Absorbed dose-rate map.

View larger version (23K): [in a new window]   FIGURE 2. Evaluation procedure.

View larger version (21K): [in a new window]   FIGURE 3. Counts in target VOI plotted as function of iteration number for HE collimator (A) and UHE collimator (B).

View larger version (37K): [in a new window]   FIGURE 4. One slice of RIT patient CT image, SPECT image, and corresponding dose-rate map.

View larger version (16K): [in a new window]   FIGURE 5. Differential dose-volume histogram corresponding to tumor outlined in patient image of Figure 4.