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Enhanced Apoptotic Reaction Correlates with Suppressed Tumor Glucose Utilization After Cytotoxic Chemotherapy: Use of ^99mTc-Annexin V, ¹⁸F-FDG, and Histologic Evaluation

¹ Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
² Department of Tracer Kinetics, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
³ Department of Radiopharmaceutical Chemistry, Health Sciences University of Hokkaido, Tobetsu, Japan
⁴ Department of Nuclear Medicine, Memorial Sloan–Kettering Cancer Center, New York, New York
⁵ Division of Nuclear Medicine, Department of Radiology, Stanford University School of Medicine, Stanford, California
⁶ Department of Laboratory Medicine, University of Washington, Seattle, Washington

View larger version (12K): [in a new window]   FIGURE 1. Time-line diagram of this study. IV = intravenously.

View larger version (16K): [in a new window]   FIGURE 2. Negative correlation between 18F-FDG uptake and 99mTc-annexin V uptake in control, gemcitabine-treated, and cyclophosphamide-treated groups. 18F-FDG uptake ((%ID/g) x kg) = 0.932 – (6.956 99mTc-annexin V uptake ((%ID/g) x kg)) (r = –0.75; P < 0.01).