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Scintigraphic Imaging of Infectious Foci with an 111In-LTB4 Antagonist Is Based on In Vivo Labeling of Granulocytes

Julliëtte E.M. van Eerd, MSc1, Wim J.G. Oyen, MD1, Thomas D. Harris, PhD2, Huub J.J.M. Rennen, PhD1, D. Scott Edwards, PhD2, Frans H.M. Corstens, MD1 and Otto C. Boerman, PhD1

1 Department of Nuclear Medicine, University Medical Centre Nijmegen, Nijmegen, The Netherlands
2 Discovery Research, Bristol-Myers Squibb Medical Imaging, North Billerica, Massachusetts



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  		FIGURE 1. Whole-body images of rabbit with E. coli thigh muscle infection (A) and healthy rabbit (B) (anterior images are shown). Rabbits received 11 MBq of 111In-DPC11870 (3 µg) intravenously. Images were acquired immediately and 1, 2, 4, 8 and 24 h after injection of 111In-DPC11870.

 


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  		FIGURE 2. Biodistribution data obtained 24 h after injection of 111In-DPC11870 in healthy rabbits (noninfected) and rabbits with intramuscular abscess (infected). Each bar represents mean value ± SD. Unpaired t test was used to analyze values for differences in uptake of radiolabel between healthy and infected animals. *P < 0.05.

 


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  		FIGURE 3. Dynamics of in vivo distribution of 111In-DPC11870 in noninfected (healthy) rabbits and rabbits with intramuscular abscess. %ID was calculated on basis of whole-body activity and is represented for total body, total blood volume, lungs, bone marrow, spleen, liver, kidneys, total muscle, and abscess. Data are mean %ID ± SD.

 


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  		FIGURE 4. Anterior images of rabbits in which intramuscular infection was induced 16 h after injection of 111In-DPC11870 (A) and healthy rabbits (B). Images were acquired from 16 h after injection of radiolabel (before induction of abscess) to 40 h after injection of radiolabel (24 h after induction of abscess).

 


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  		FIGURE 5. Anterior images of rabbits in which intramuscular infection was induced and 4 MBq of 111In-DPC11870 (A), 111In-DPC11870-BMCs (B), or 111In-DPC11870-WBCs (C) were injected. Images were acquired immediately after injection of radiolabeled compound and at 2, 6, and 24 h after injection

 


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  		FIGURE 6. Biodistribution data obtained 24 h after injection of 111In-DPC11870, 111In-DPC11870-BMCs, or 111In-DPC11870-WBCs. Data are %ID/g in individual organ or tissue.

 




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