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Characterization of 68Ga-DOTA-D-Phe1-Tyr3-Octreotide Kinetics in Patients with Meningiomas

Marcus Henze, MD1, Antonia Dimitrakopoulou-Strauss, MD2, Stefanie Milker-Zabel, MD3, Jochen Schuhmacher, PhD4, Ludwig G. Strauss, MD2, Josef Doll, PhD5, Helmut R. Mäcke, PhD6, Michael Eisenhut, PhD4, Jürgen Debus, MD3 and Uwe Haberkorn, MD1,2

1 Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
2 Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
3 Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
4 Division of Radiochemistry and Radiopharmacology, German Cancer Research Center, Heidelberg, Germany
5 Department of Innovative Cancer Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany
6 University Hospital Basel, Basel, Switzerland



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  		FIGURE 1. Two-tissue-compartment model with blood compartment.

 


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  		FIGURE 2. (A) Transaxial fusion images (gadolinium-DTPA-enhanced MRI in black and white; 68Ga-DOTA-TOC PET in green) show high tracer uptake by meningioma in left sphenoid wing, with infiltration into left cavernous sinus and physiologic uptake by pituitary gland (arrow). (B) Fitted time-activity curves are shown for volumes of interest covering meningioma and an arterial vessel. Corresponding kinetic parameters of meningioma were calculated with PMod software.

 


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  		FIGURE 3. Box plots of SUVs for meningiomas, RT, and normal brain tissue. Boundary of box closest to zero indicates 25th percentile, line within box indicates median, and boundary of box farthest from zero indicates 75th percentile. Whiskers above and below box indicate 90th and 10th percentiles. Outlying values are graphed as dots.

 


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  		FIGURE 4. Box plots of vB (A) and RB (B) for meningiomas and RT.

 


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  		FIGURE 5. Box plots of k1 (A), k2 (B), and k1/k2 (C) for meningiomas and RT.

 


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  		FIGURE 6. Box plots of k3 (A) and k4 (B) for meningiomas and RT.

 




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