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Attenuation Correction of Myocardial SPECT Perfusion Images with Low-Dose CT: Evaluation of the Method by Comparison with Perfusion PET

¹ Institute of Molecular Biophysics, Radiopharmacy and Nuclear Medicine, Heart and Diabetes Center North Rhine-Westphalia, Bad Oeynhausen, Germany
² Diabetes Clinic, Heart and Diabetes Center North Rhine-Westphalia, Bad Oeynhausen, Germany

View larger version (43K): [in a new window]   FIGURE 1. Polar maps display mean perfusion (PET) and mean uptake (SPECT) of 23 normalized patient studies. Top row, rest studies. Bottom row, stress studies. (A) Mean perfusion per segment, PET. (B) Mean uptake per segment, SPECT without attenuation correction (NC). (C) Mean uptake per segment, SPECT with attenuation correction (AC).

View larger version (44K): [in a new window]   FIGURE 2. Comparison of SPECT uptake, without (NC) and with attenuation correction (AC), with PET perfusion. Top row, rest studies. Bottom row, stress studies. (A) Mean differences between NC SPECT and PET perfusion. (B) Mean differences between AC SPECT and PET perfusion. 0 = no significant difference between regional SPECT uptake and regional PET perfusion.

View larger version (45K): [in a new window]   FIGURE 3. SPECT without (NC) and with attenuation correction (AC) compared with 13N-ammonia uptake (based on 4D-MSPECT). Top row, rest studies. Bottom row, stress studies. (A) Mean differences between NC SPECT and PET uptake. (B) Mean differences between AC SPECT and PET uptake. 0 = no significant difference between regional SPECT uptake and regional 13N-ammonia uptake.

View larger version (46K): [in a new window]   FIGURE 4. Comparison of SPECT without (NC) and with attenuation correction (AC) with smoothed PET 13N-ammonia uptake. Top row, rest studies. Bottom row, stress studies. (A) Mean differences between NC SPECT and 13N-ammonia uptake from smoothed images. (B) Mean differences between AC SPECT and 13N-ammonia uptake from smoothed images. 0 = no significant difference between regional SPECT uptake and regional 13N-ammonia uptake (smoothed images).

View larger version (34K): [in a new window]   FIGURE 5. Linear regression of SPECT and PET segments. Top row, rest studies. Bottom row, stress studies. (A) SPECT relative uptake vs. PET relative perfusion. (B) SPECT relative uptake vs. PET relative uptake. (C) SPECT relative uptake vs. PET relative uptake (smoothed). Regression coefficient (r2) is given.