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Biodistribution and Radiation Dosimetry of ¹¹C-WAY100,635 in Humans

¹ Division of Brain Imaging, Department of Neuroscience, New York State Psychiatric Institute, New York, New York
² Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York
³ Department of Radiology, Columbia University College of Physicians and Surgeons, New York, New York
⁴ Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee

View larger version (50K): [in a new window]   FIGURE 1. Representative whole-body scan of a woman after bolus injection of 11C-WAY100,635. Acquisitions from frame 1 (0–6 min) (A and E), frame 2 (10–16 min) (B and F), frame 3 (20–30 min) (C and G), and frame 5 (56–72 min) (D and H) in coronal (A–D) and transaxial (E–H) planes sometimes spanned 2 bed positions (D). Time–activity curves were obtained for each ROI at each bed position.

View larger version (17K): [in a new window]   FIGURE 2. Time–activity curves generated from ROIs shown in Figure 1. Initial fast distribution of radiotracer throughout most of the body, with slower accumulation in kidneys, is followed by accumulation in urinary bladder, suggesting that major route of elimination is urinary system. Solid circles indicate activity in ROI as percentage of injected dose. Area under curve is determined by trapezoidal integration of first 3 time points through origin and integration of single exponential fit through final 3 time points. Time points are different in different organs as organs occupy different bed positions. Solid squares and dashed lines indicate decay-corrected time–activity curve.

View larger version (11K): [in a new window]   FIGURE 3. Comparison of radiation dose estimate from in vivo human PET studies and ex vivo rat biodistribution and dosimetry studies with all data points (A) and without urinary bladder and kidneys (B). Solid line in both plots is identity.