HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hockaday, D. C. Articles by Mamelak, A. N. Search for Related Content PubMed PubMed Citation Articles by Hockaday, D. C. Articles by Mamelak, A. N.

Imaging Glioma Extent with ¹³¹I-TM-601

¹ Neurosurgery Section, Department of General and Oncological Surgery, City of Hope Cancer Center, Duarte, California
² Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama
³ Department of Radio-Immunotherapy, Beckman Research Institute, City of Hope Cancer Center, Duarte, California
⁴ Transmolecular, Inc., Birmingham, Alabama

View larger version (83K): [in a new window]   FIGURE 1. Total-body planar images show distribution of 131I-TM-601 immediately after injection (A) and 8 d later (B). Long-term retention of radioactivity at tumor site, with nearly complete elimination elsewhere, was observed in all patient scans. The 7.4-MBq (200 µCi) standard is at bottom.

View larger version (16K): [in a new window]   FIGURE 2. Graph of average SPECT decay shows that normalized intensity of brightest voxel averaged over all patients drops significantly in 2 d. Expon. = exponential physical decay of 7.4-MBq (200 µCi) sample of 131I-Tm-601 standard over data collection period.

View larger version (13K): [in a new window]   FIGURE 3. Comparison of T1-Wc MRI-, T2-weighted MRI-, and SPECT-determined tumor volume estimates on day 2.

View larger version (10K): [in a new window]   FIGURE 4. Comparison of T1-weighted MRI-, T2-weighted MRI-, and SPECT-determined tumor volume estimates on day 8. SPECT day 2 estimates exhibit more uncertainty and generally larger volumes than those on day 8. SPECT day 8 estimates are more centered (but still closer to T2 estimate) and more reliable.

View larger version (49K): [in a new window]   FIGURE 5. Axial view of T1-Wc (A), coregistered (B), and SPECT (day 8) images.

View larger version (60K): [in a new window]   FIGURE 6. Coregistered MR/SPECT images for patient 5 on day 2 (A), day 3 (B), and day 8 (C) after injection.