Myocardial 11C-Diacylglycerol Accumulation and Left Ventricular Remodeling in Patients After Myocardial Infarction
Hiroki Otani, MD, PhD1,
Yutaka Kagaya, MD, PhD1,
Yoshio Imahori, MD, PhD2,
Satoshi Yasuda, MD, PhD3,
Ryo Fujii, PhD4,
Masanobu Chida, MD, PhD1,
Shigeto Namiuchi, MD, PhD1,
Morihiko Takeda, MD, PhD1,
Masahito Sakuma, MD, PhD1,
Jun Watanabe, MD, PhD1,
Tatsuo Ido, PhD5,
Hiroshi Nonogi, MD, PhD3 and
Kunio Shirato, MD, PhD1
1 Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
2 Department of Neurosurgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
3 Division of Cardiology, National Cardiovascular Center, Osaka, Japan
4 Nishijin Hospital, Kyoto, Japan
5 Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
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FIGURE 1. Representative short axial slices of PET with 11C-DAG in healthy volunteer (A) and 2 post-MI patients (B and C). In healthy volunteer, myocardial accumulation of 11C-DAG was mild and myocardium-to-LA chamber ratio of 11C-DAG was 1.28 (A). In post-MI patient 6, myocardial accumulation of 11C-DAG was also mild and myocardium-to-LA chamber ratio of 11C-DAG was 1.39 (B). In patient 4, a remarkable accumulation of 11C-DAG was observed in remote viable myocardium (inferior septum and inferolateral wall). Myocardium-to-LA chamber ratio of 11C-DAG was 2.58 (C).
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FIGURE 2. Myocardium-to-LA chamber ratio of 11C-DAG in healthy volunteers and post-MI patients. *P < 0.05.
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FIGURE 3. Correlations between myocardium-to-LA chamber ratio of 11C-DAG and LVEDVI (A), LVEF (B), and plasma concentration of BNP (C). LVEDVI = left ventricular end-diastolic volume index; LVEF = left ventricular ejection fraction.
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Copyright © 2005 by the Society of Nuclear Medicine.
