HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yau, Y.-Y. Articles by Chu, S. K.-F. Search for Related Content PubMed PubMed Citation Articles by Yau, Y.-Y. Articles by Chu, S. K.-F.

Application of Intravenous Contrast in PET/CT: Does It Really Introduce Significant Attenuation Correction Error?

¹ Department of Nuclear Medicine and PET-CT, AmMed Cancer Center, Adventist Hospital, Hong Kong, China
² General Electric Medical Systems, Milwaukee, WI
³ The Hamamatsu/Queen’s PET Imaging Center, Honolulu, HI

View larger version (97K): [in a new window]   FIGURE 1. In part I, there was no visually mismatched 18F-FDG uptake in PET 1 (A) and PET 2 (B) from pathologic region.

View larger version (90K): [in a new window]   FIGURE 2. In part II, there was no visually mismatched 18F-FDG uptake in PET 3 (A) and PET 4 (B).

View larger version (126K): [in a new window]   FIGURE 3. Representative images of sampling method using ROI copy-and-paste method for CT and PET with and without intravenous contrast to reproduce same site. Three different arrows are used to demonstrate ROI selection.

View larger version (16K): [in a new window]   FIGURE 4. Representative graphs of SUVmax of target tissues derived from NCCT and CECT in part I. Spleen (A), liver (B), and pathology (C) showed significant upward trend.

View larger version (33K): [in a new window]   FIGURE 5. Part II: correlation between SUVmax and HU in noncontrast and contrast studies from 2 representative tissues. (A) SUV graph of liver: statistically insignificant tissue had numerous decreasing lines with contrast. (B) HU graph of liver revealed obvious upward trend. (C) SUV graph of T11/T12, statistically significant tissue, generally showed upward trend. (D) HU graph of T11/T12 exhibited random upward and downward trend.

View larger version (14K): [in a new window]   FIGURE 6. (A) Relationship between body mass and HU of spleen. There was statistically significant rise in HU after intravenous contrast. Increase in HU was greatest for smaller patients. (B) Relationship between change in CT number (HU) due to contrast agent and effect on measured SUVmax in part II. There was poor correlation between difference in CT number and difference in SUVmax.

View larger version (58K): [in a new window]   FIGURE 7. There was no significant 18F-FDG uptake in right kidney on PET image. However, right renal cell carcinoma (arrow) would have been easily missed without use of contrast in CT image.