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Does Lemon Candy Decrease Salivary Gland Damage After Radioiodine Therapy for Thyroid Cancer?

Kunihiro Nakada, MD, PhD1, Tetsuya Ishibashi, MD1, Toshiki Takei, MD1, Kenji Hirata, MD1, Katsura Shinohara, MD1, Seiichi Katoh, MD1, Sonji Zhao, MD, PhD1, Nagara Tamaki, MD, PhD1, Yasushi Noguchi, MD2 and Shiro Noguchi, MD, PhD2

1 Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
2 Noguchi Thyroid Clinic and Hospital Foundation, Beppu, Japan



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  		FIGURE 1. Typical time–activity curves of 99mTcO4– for bilateral parotid glands in patients with postsurgical thyroid cancer after high-dose radiodione therapy. Solid line is curve for right parotid gland; dashed line is curve for left parotid gland. (A) Normal: Lemon juice was administered at 20 min after injection of 99mTcO4– ({downarrow}). (B) Mild to moderately hypofunctioning (lower curve) and obstructive (upper curve). (C) Severely hypofunctioning. (D) Nonfunctioning.

 


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  		FIGURE 2. Early and late side effects of high-dose radioiodine therapy on salivary glands in group A patients (pts).

 


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  		FIGURE 3. Early and late side effects of high-dose radioiodine therapy on salivary glands in group B patients (pts).

 


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  		FIGURE 4. Power mode Doppler ultrasonography in healthy subject at rest (right) and at simulated condition by lemon candy (left). By use of lemon candy, contraction of gland was associated with increase in blood flow (orange color).

 




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