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18F-FDG PET Findings in Frontotemporal Dementia: An SPM Analysis of 29 Patients

Yong Jeong, MD, PhD1, Sang Soo Cho, MS2, Jung Mi Park, MD3, Sue J. Kang, MS1, Jae Sung Lee, PhD2, Eunjoo Kang, PhD2, Duk L. Na, MD, PhD1 and Sang Eun Kim, MD, PhD2

1 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
2 Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
3 Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea



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FIGURE 1. Hypometabolic regions in patients with FTD compared with healthy controls. These regions are displayed on surface-rendered (top) and transaxial (bottom) images. Hypometabolic regions were displayed according to 2 different thresholds in green (P < 0.01; corrected, T = 5.18) and red (P < 0.0005; corrected, T = 6.29). Number in each transaxial brain image indicates distance (mm) from anterior commisure–posterior commisure plane.

 


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FIGURE 2. Hypometabolic regions in individual patients with FTD compared with the healthy control group (P < 0.001, uncorrected).

 


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FIGURE 3. Scatter plots showing distribution of AIROI and AISPM values in patients with FTD. Positive AIROI and AISPM values indicate that right hemisphere was more hypometabolic than left hemisphere; negative values indicate the opposite. Closed circles denote significant hemispheric metabolic asymmetry.

 





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