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Striatal Dopamine Transporter Imaging Correlates with Anxiety and Depression Symptoms in Parkinson’s Disease

Daniel Weintraub, MD1,2, Andrew B. Newberg, MD3, Mark S. Cary, PhD4, Andrew D. Siderowf, MD, MSCE5, Paul J. Moberg, PhD1,2, Galit Kleiner-Fisman, MD2,5, John E. Duda, MD2,5, Matthew B. Stern, MD2,5, David Mozley, MD6 and Ira R. Katz, MD, PhD1

1 Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania
2 Parkinson’s Disease Research, Education, and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania
3 Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
4 Department of Biostatistics and Epidemiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
5 Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania
6 Eli Lilly, Lilly Corporate Center; Indianapolis, Indiana



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  		FIGURE 1. TRODAT-1 SPECT image of healthy volunteer (control) demonstrating ROI analysis for caudate, anterior putamen, and posterior putamen (shown within a larger region outlining the striatum).

 


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  		FIGURE 2. Association between total affect score and left anterior putamen DAT availability.

 




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