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Assessment of the Long-Term Reproducibility of Baseline and Dobutamine-Induced Myocardial Blood Flow in Patients with Stable Coronary Artery Disease

Rohan Jagathesan, MBBS1,2, Philipp A. Kaufmann, MD1, Stuart D. Rosen, MD2, Ornella E. Rimoldi, MD1,2, Federico Turkeimer, PhD1, Rodney Foale, MD2 and Paolo G. Camici, MD1,2

1 Medical Research Council Clinical Sciences Centre, Imperial College, London, United Kingdom
2 National Heart and Lung Institute, Imperial College, London, United Kingdom



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  		FIGURE 1. Study protocol used for measurement of MBF using H215O and PET (ECAT 931-08/12 scanner) at rest and during Dob hyperemia, performed at baseline (t = 0) and repeated after 24 wk (t = 24).

 


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  		FIGURE 2. Individual resting and Dob MBF measured at baseline (1) and after 24 wk (2) in ischemic (Isc, A and B) and remote (Rem, C and D) myocardium. Paired values are given for each participant.

 


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  		FIGURE 3. Repeatability of regional MBF measurements in ischemic (Isc, A and B) and remote (Rem, C and D) myocardial territories. Difference of 2 MBF measurements at rest (A and C) and during Dob hyperemia (B and D) is plotted against their average value (Bland-Altman plot).

 


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  		FIGURE 4. Repeatability of CFR measured at baseline (1) and after 24 wk (2) in ischemic (Isc, A) and remote (Rem, B) myocardial territories. Differences of values are plotted against their average value (Bland-Altman plot).

 




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