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MIBG and Somatostatin Receptor Analogs in Children: Current Concepts on Diagnostic and Therapeutic Use

¹ Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa
² Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa

View larger version (41K): [in a new window]   FIGURE 1. 131I-MIBG and 111In-DTPA-octreotide images of patient with neuroblastoma. (A) 131I-MIBG images at 48 h demonstrate diffuse abnormal bone marrow uptake in proximal upper and lower extremities and in spine. (B) 111In-DTPA-octreotide images at 24 h show abnormal bone marrow uptake in a similar distribution. 111In-DTPA-octreotide also shows subtle focus at superior aspect of right lobe of liver, which is not appreciated on MIBG scan (arrowhead). Bone marrow disease was confirmed with biopsy. CT of the abdomen showed multiple liver lesions.

View larger version (29K): [in a new window]   FIGURE 2. 131I-MIBG and 111In-DTPA-octreotide images of a patient with neuroblastoma. Patient, complaining of right hip pain, was imaged for recurrence 1 y after chemotherapy and bone marrow transplant. (A) 131I-MIBG showed abnormal uptake in right hip (arrow). Markers at level of elbow (E) and anterior superior iliac spine (ASIS). No abnormal uptake of 131I-MIBG noted in spine. (B) 111In-DTPA-octreotide showed abnormal uptake in right hip (arrow), diffuse uptake in marrow of thoracic and lumbar spine (dashed arrow), and focal uptake in midthoracic spine (arrow). Bone marrow biopsy confirmed recurrent disease. MR imaging showed increased enhancement posterior to right acetabulum.