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Antibody-Based Targeted Radiation to Pediatric Tumors

Shakeel Modak, MD; and Nai-Kong V. Cheung, MD, PhD

Department of Pediatrics, Memorial Sloan–Kettering Cancer Center, New York, New York



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  		FIGURE 1. Gamma-camera scan of a child with recurrent stage 4 neuroblastoma, imaged 48 h after injection of 131I-3F8 and showing diffuse metastases in skull and axial and appendicular skeleton. Also notable is the absence of nonspecific uptake in liver or spleen. Figures show uptake of 131I-3F8 in (A) left lateral skull; (B) anterior skull; (C) anterior torso; (D) right lateral skull; (E) lower extremities; and (F) posterior torso.

 


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  		FIGURE 2. CT image of a child with recurrent MYNC-amplified neuroblastoma. Paraspinal soft tissue mass before (A) and after (B) 131I-3F8 therapy.

 




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