Comparison of Changes in Tumor Metabolic Activity and Tumor Size During Chemotherapy of Adenocarcinomas of the Esophagogastric Junction
Hinrich A. Wieder, MD1,
Ambros J. Beer, MD2,
Florian Lordick, MD3,4,
Katja Ott, MD4,
Michael Fischer, MD2,
Ernst J. Rummeny, MD2,
Sibylle Ziegler, PhD1,
Jörg R. Siewer, MD4,
Markus Schwaiger, MD1 and
Wolfgang A. Weber, MD1
1 Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
2 Department of Radiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
3 Department of Hematology and Oncology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
4 Department of Surgery, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
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FIGURE 1. Time course of changes in tumor 18F-FDG uptake and tumor wall thickness. Error bars denote 1 SEM.
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FIGURE 2. MSCT and 18F-FDG PET in patient before chemotherapy (CTx), after 14 d of therapy, and before surgery. Tumor size (arrow) was almost unchanged in MSCT after 14 d of therapy but showed significant decrease after completion of therapy. However, 18F-FDG uptake by tumor after 14 d of therapy showed distinct decrease and was reduced to background levels in scan before surgery.
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FIGURE 3. Correlation between early changes in 18F-FDG uptake and early (A) and late (B) changes in tumor size.
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FIGURE 4. Relationship between early and late changes in tumor metabolism and size. (A) Correlation between early and late changes in tumor metabolism. (B) Correlation between early and late changes in tumor size.
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Copyright © 2005 by the Society of Nuclear Medicine.
