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Gated Cardiac 13N-NH3 PET for Assessment of Left Ventricular Volumes, Mass, and Ejection Fraction: Comparison with Electrocardiography-Gated 18F-FDG PET

Aliasghar Khorsand, PhD1, Senta Graf, MD1, Harald Eidherr, MD2, Wolfgang Wadsak, MD2, Kurt Kletter, MD2, Heinz Sochor, MD1, Ernst Schuster, PhD3 and Gerold Porenta, MD, PhD4

1 Department of Cardiology, Medical University of Vienna, Vienna, Austria
2 Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
3 Department of Medical Computer Sciences, Medical University of Vienna, Vienna, Austria
4 Rudolfinerhaus, Vienna, Austria



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  		FIGURE 1. Example of model-based parameter estimation of cardiac geometry. Short-axis images obtained at basal, midventricular, and apical levels (left to right) were derived from 13N-NH3 (A) and 18F-FDG (B) PET studies for end-diastolic (upper 2 rows) and end-systolic (lower 2 rows) time points. Second and fourth rows depict short-axis views with overlays of estimated endocardial and epicardial contours.

 


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  		FIGURE 2. Regression analysis and Bland–Altman plots of ESV (A and B) and EDV (C and D) determined from 13N-NH3 and 18F-FDG PET images. Dashed lines in A and C are lines of identity (13N-NH3 value equals 18F-FDG value). Mean differences and 95% confidence limits (±2 SDs) in B and D are represented by solid and dashed lines, respectively.

 


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  		FIGURE 3. Regression analysis and Bland–Altman plots of LVEF (A and B) and LVMM (C and D) determined from 13N-NH3 and 18F-FDG PET images. Dashed lines in A and C are lines of identity (13N-NH3 value equals 18F-FDG value). Mean differences and 95% confidence limits (±2 SDs) in B and D are represented by solid and dashed lines, respectively.

 




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