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Relationship Between Brachial Artery Flow–Mediated Dilation and Coronary Flow Reserve in Patients with Peripheral Artery Disease

Teresa Pellegrino, MD1, Giovanni Storto, MD1,2, Pasquale Perrone Filardi, MD, PhD3, Anna Rita Sorrentino, MD, PhD1, Antonio Silvestro, MD3, Mario Petretta, MD3, Gregorio Brevetti, MD3, Massimo Chiariello, MD3, Marco Salvatore, MD1,2 and Alberto Cuocolo, MD1,2

1 Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy
2 Institute of Biostructure and Bioimages, National Council of Research, Napoli, Italy
3 Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy



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FIGURE 1. Mean ± SD CFR estimated by 99mTc-sestamibi imaging in control subjects (controls) and in patients with PAD and brachial artery FMD above (group 1) or below (group 2) median. *P < 0.001 vs. control subjects. {dagger}P < 0.001 vs. group 1.

 


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FIGURE 2. Individual values for CFR ({circ}) estimated by 99mTc-sestamibi imaging in control subjects (controls) and in patients with PAD (patients). •, mean ± SD.

 


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FIGURE 3. Relationship between brachial artery FMD and CFR estimated by 99mTc-sestamibi imaging in patients with PAD, with no cardiac symptoms, and without evidence of CAD at stress SPECT.

 





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