A 18F-MPPF PET Normative Database of 5-HT1A Receptor Binding in Men and Women Over Aging

A ¹⁸F-MPPF PET Normative Database of 5-HT_1A Receptor Binding in Men and Women Over Aging

Nicolas Costes, MSc¹^,2, Isabelle Merlet, PhD³^,4, Karine Ostrowsky, MD³, Isabelle Faillenot, PhD⁵, Franck Lavenne, BSc¹^,4, Luc Zimmer, PharmD, PhD¹^,6, Philippe Ryvlin, MD, PhD³^,6 and Didier Le Bars, PharmD, PhD¹^,6

¹ Imagerie du vivant, PET Centre, Centre d’Etude et de Recherche Multimodales et Pluridisciplinaires, Lyon, France
² Centre Nationale de la Recherche Scientifique, Paris, France
³ Équipe d’Accueil 1880, Neurological Hospital, Lyon, France
⁴ Institut National de la Santé et de la Recherche Médicale, Paris, France
⁵ Institut Fédératif des Neurosciences de Lyon, Lyon, France
⁶ Université Claude Bernard de Lyon, Lyon, France

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FIGURE 1. Scatter plot of BP values for 53 subjects in 18 anatomic ROIs manually delineated on individual MR images. Left and right values are not differentiated. Triangles are for female data, and dots are for male data. Linear regression curves are plotted for females (solid line) and for males (dashed line) independently. NS = not significant; R² = correlation coefficient.

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FIGURE 2. SPM of ¹⁸F-MPPF binding with age and sex effect (analysis II). (A and B) Increase in ¹⁸F-MPPF binding in female compared with male subjects independently of age effect. (A) Maximum intensity projection (MIP) in the x-, y-, and z-directions of the statistical map. t score threshold P < 0.001 uncorrected for multiple comparisons; cluster threshold P < 0.05 corrected for multiple comparisons. Right of the brain is the right of the figure. (B) Three orthogonal views (x, y, z = 66, –22, –14) of SPM centered on peak situated in right middle temporal gyrus (Boadmann’s area [BA] 21) superimposed on averaged normalized MR images from 23 female subjects. Right hippocampus is visible on right hemisphere in transverse and coronal views. (C) Binding of ¹⁸F-MPPF increase in male vs. female independent of age effect. Transverse view of SPM shows a side effect in surface of parietal cortex (x, y, z = 36, –78, 46). (D and E) Negative linear correlation of BP with age in female subjects. (D) MIP of statistical map. t score’s threshold P < 0.001 uncorrected for multiple comparisons; cluster threshold P < 0.05 corrected for multiple comparisons. (E) Three orthogonal views of SPM centered on peak situated in right superior temporal gyrus (x, y, z = 48, –19, –5; BA 22) superimposed on averaged normalized MR images from 23 female subjects. (F) Positive linear correlation of BP with age in male population. Three orthogonal views of SPM (t threshold P < 0.001 uncorrected; cluster threshold P < 0.05 corrected, x, y, z = –8, 64, –18) centered on peak situated in left middle frontal gyrus (BA 11) superimposed on averaged normalized MR images from 22 male subjects. Rectus gyrus is visible on sagittal and transverse views.

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FIGURE 3. SPM of ¹⁸F-MPPF binding by decade of age (analysis III). (A and B) SPM of differences between decades in female population. (A) Decrease in ¹⁸F-MPPF binding between subjects in their 40s and their 50s in right superior temporal gyrus (sagittal view, x = 54 mm; transverse view, z = –8 mm). (B) Increase in ¹⁸F-MPPF binding from 50s to 60s decades of age in left fusiform gyrus (sagittal view, x = –44 mm; coronal view, y = –70 mm). (C and D) SPM of differences between decade of age in male population: decrease in ¹⁸F-MPPF binding between subjects in their 20s and 30s. (C) Sagittal view (x = –10 mm): Decrease in left posterior cingulate gyrus (cross), superior parietal lobule, and superior frontal gyrus. (D) Transverse view (z = +44 mm), decrease in left inferior parietal lobule (cross). BP values appear symmetric in right inferior parietal, left posterior cingulate, and left middle frontal cortex. (E and F) SPM of differences between decades in female population: Increase in ¹⁸F-MPPF binding between subjects in their 30s and 40s. (E) Sagittal view (x = +6 mm), right middle frontal gyrus (BA 9). (F) Transverse view (z = 32 mm), left middle frontal gyrus.