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Reproducibility of 3'-Deoxy-3'-¹⁸F-Fluorothymidine MicroPET Studies in Tumor Xenografts in Mice

¹ Molecular Imaging Program of Stanford, Bio-X Program, and Department of Radiology, Stanford University School of Medicine, Stanford, California
² Department of Radiology, University of California, Los Angeles, Los Angeles, California
³ Department of Pharmacy, University of Southern California, Los Angeles, California

View larger version (17K): [in a new window]   FIGURE 1. Competition between various concentrations of thymidine and 3H-FLT in C6 rat glioma cells. Accumulation values represent tracer activity relative to activity in medium, normalized to total protein. Thymidine concentrations are plotted on log scale. Error bars represent 1 SD for triplicate samples.

View larger version (15K): [in a new window]   FIGURE 2. Correlation between mouse serum thymidine levels determined by LC-MS/MS and 18F-FLT accumulation in 6 nude mice with C6 rat glioma xenografts. Accumulation values represent %ID/g values from ROI analysis of tumor xenografts from microPET images.

View larger version (29K): [in a new window]   FIGURE 3. 3D volume renderings of nude mouse C6 tumor xenograft scans showing reproducibility of 18F-FLT microPET. (Left) First scan. (Right) Second scan obtained 6 h later, after second injection of 18F-FLT. Mean %ID/g values are shown adjacent to tumor xenografts.

View larger version (29K): [in a new window]   FIGURE 4. 3D volume renderings of nude mouse C6 tumor xenograft scans obtained 1 h (left) and 4 h (right) after single 18F-FLT injection by microPET and showing changes in tumor activity and tracer distribution over time. Mean %ID/g values are shown adjacent to tumor xenografts.

View larger version (30K): [in a new window]   FIGURE 5. 3D volume renderings of nude mouse C6 tumor xenograft scans displaying temperature dependence of 18F-FLT microPET at 2 different temperatures, 24°C (left) and 35°C (right). Mean %ID/g values are shown adjacent to tumor xenografts.