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Rapid Scanning Protocol for Brain 18F-FDG PET: A Validation Study

Wei Ping Chen, MD, PhD1,2, Ichiro Matsunari, MD, PhD2, Akihiro Noda, PhD2, Daisuke Yanase, MD, PhD3, Kazuyoshi Yajima, PhD1,2, Nozomi Takeda1,2, Masahito Yamada, MD, PhD3, Satoshi Minoshima, MD, PhD4 and Shintaro Nishimura, PhD2

1 Ishikawa Sunrise Industries Creation Organization, Kanazawa, Japan
2 Medical and Pharmacological Research Center Foundation, Hakui, Japan
3 Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
4 Department of Radiology, University of Washington, Seattle, Washington



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  		FIGURE 1. Schematic representation of rapid and conventional scanning protocols.

 


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  		FIGURE 2. Kinetic model used in simulation study. BBB = blood–brain barrier; 18F-FDG-6-P = 18F-FDG-6-phosphate.

 


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  		FIGURE 3. (A) Comparison of normalized values between the 2 scanning protocols in healthy group. (B) Comparison of z values between the 2 scanning protocols in patient group. Error bars show SD of normalized values or z values in each scanning protocol. ACING = anterior cingulate gyrus; CBL = cerebellar hemisphere; FRT = frontal cortex; MFRT = medial frontal association cortex; MPRT = medial parietal association cortex; OCT = occipital cortex; PCING = posterior cingulate gyrus; PNS = pons; PRT = parietal cortex; SMC = primary sensorimotor cortex; TMP = temporal cortex; VC = primary visual cortex; VER = cerebellar vermis.

 


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  		FIGURE 4. (A and B) Mean normalized activity and CV images obtained from conventional (A) and rapid (B) scanning protocols in healthy group. (C) z (rapid – conventional) images showing differences between the 2 protocols.

 


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  		FIGURE 5. (A and B) Mean z image and CV images obtained from conventional (A) and rapid (B) scanning protocols in patient group. z (1 case) are z images of 1 patient with probable AD. (C) z (rapid – conventional) image showing differences between the 2 protocols.

 


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  		FIGURE 6. ROC curves obtained from conventional- and rapid-protocol images with large z values, indicative of true-positive cases in area of posterior cingulate gyri and precunei (A) and lateral parietal association cortex (B).

 


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  		FIGURE 7. Simulated time–activity curves in each region (left) and calculated values corresponding to the 2 protocols, normalized by mean value of cortical regions (right). CAD = caudate; CBL = cerebellum; FRT = frontal cortex; OCT = occipital cortex; PRT = parietal cortex; THL = thalamus; TMP = temporal cortex.

 




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