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In Vivo Measurement of Brain Monoamine Oxidase B Occupancy by Rasagiline, Using 11C-L-Deprenyl and PET

Nanette M.T. Freedman, PhD1, Eyal Mishani, PhD1, Yodphat Krausz, MD1, Jolie Weininger, PhD1, Hava Lester, PhD1, Eran Blaugrund, PhD2, Daphna Ehrlich, PhD2 and Roland Chisin, MD1

1 Department of Medical Biophysics and Nuclear Medicine, Hadassah University Hospital, Jerusalem, Israel
2 Teva Pharmaceuticals, Netanya, Israel



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  		FIGURE 1. Summary of 11C-L-deprenyl images: average activity distribution for all 3 subjects in 1 image slice on each of the 4 scans—before (scan 1), immediately after (scan 2), and 2–3 (scan 3) and 4–6 wk (scan 4) after treatment with rasagiline. Color on all images is adjusted to same absolute scale of intensities.

 


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  		FIGURE 2. Comparison of 11C-L-deprenyl activity concentrations (30–70 min after injection) in brain regions on scans 1–4 (average over 3 subjects). Cortex includes frontal, occipital, parietal, and temporal cortices. Error bars indicate ±1 SD.

 


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  		FIGURE 3. 11C activity concentrations (expressed as percentage injected dose [%ID] x 1,000/g) in whole-blood samples taken 30 min after injection during scans 1–4. Error bars indicate range of values.

 


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  		FIGURE 4. Average time–activity curves for basal ganglia (A), thalamus (B), cerebellum (C), and cortex (D) (including frontal, occipital, parietal, and temporal cortices) from 0 to 90 min after injection on scans 1–4.

 


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  		FIGURE 5. Comparison of modified Patlak slope ratios (relative to white matter) for brain regions on scans 1–4 (average over 3 subjects). Cortex includes frontal, occipital, parietal, and temporal cortices. Error bars indicate ±1 SD.

 




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