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Myocardial Blood Flow Measurement by PET: Technical Aspects and Clinical Applications

¹ Nuclear Cardiology Section, Cardiovascular Center, University Hospital, Zurich, Switzerland
² Faculty of Medicine, Medical Research Council Clinical Sciences Centre, Imperial College, London, United Kingdom

View larger version (35K): [in a new window]   FIGURE 1. Scatterplot shows relationship between age and hyperemic MBF, illustrating lower hyperemic MBF in subjects >55 y old. Similarly, in the few youngest subjects, hyperemic MBF was also lower than the group mean. (Reprinted with permission of (71).)

View larger version (14K): [in a new window]   FIGURE 2. CFR is significantly lower in asymptomatic smokers than in healthy control subjects. This can be reversed by short-term infusion of high-dose vitamin C. (Reprinted with permission of (59).)

View larger version (40K): [in a new window]   FIGURE 3. CFR (arbitrary units) during therapy with fluvastatin. *P < 0.05 vs. baseline. (Reprinted with permission of (127).)

View larger version (13K): [in a new window]   FIGURE 4. MBF values after dipyridamole infusion and long-term prognosis in HCM. Patients were divided into 3 equal groups according to MBF after dipyridamole infusion. (A) Overall cumulative suvival. (B) Cumulative survival free from unfavorable outcome. (Reprinted with permission of (62).)

View larger version (27K): [in a new window]   FIGURE 5. (Top) Kaplan-Meier plots obtained in DCM patients with dipyridamole MBF of >1.36 mL·min–1·g–1 irrespective of New York Heart Association (NYHA) class (A) and in patients with dipyridamole MBF of 1.36 mL·min–1·g–1 subdivided according to absence (NYHA class I) (B) or presence (NYHA classes II and III) (C) of heart failure symptoms at enrollment. (Bottom) Kaplan-Meier plots obtained in patients with dipyridamole MBF of >1.36 mL·min–1·g–1 irrespective of left ventricular end-diastolic dimension (A) and in patients with dipyridamole MBF of 1.36 mL·min–1·g–1 subdivided according to left ventricular end-diastolic dimension of 60 mm (B) or >60 mm (C) at enrollment. (Reprinted with permission of (190).)

View larger version (17K): [in a new window]   FIGURE 6. (Top) No significant association was found between MBF at rest and degree of stenosis. Hyperemic MBF decreased significantly as stenosis severity increased. (Reproduced with permission of (61).). (Bottom) Scatterplot of relation between myocardial flow reserve and quantitative coronary angiographic measurements of percent area stenosis (r = 0.78, root mean square error = 0.61, P < 0.00001). (Reprinted with permission of (215).)