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Corn Oil Emulsion: A Simple Cholecystagogue for Diagnosis of Chronic Acalculous Cholecystitis

Division of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa

View larger version (19K): [in a new window]   FIGURE 1. Gallbladder time–activity curves show change in gallbladder activity over time. (A) Abnormal time–activity curve shows 0% clearance of activity by 30 min, 10% by 60 min, and 8% by 90 min. (B) Normal time–activity curve with 29% clearance by 30 min, 52% by 60 min, and 81% by 90 min.

View larger version (10K): [in a new window]   FIGURE 2. Raw data distribution of 30- and 60-min GBEFs in 30 patients and 90-min GBEFs in 26 patients including mean ± SD bar shown at each measurement. Differences in mean 30-, 60-, and 90-min GBEFs between 2 groups of patients (normal vs. CAC) were statistically significant (P < 0.007).

View larger version (7K): [in a new window]   FIGURE 3. Raw data distribution of GBFs for study subjects at 30 min (n = 30) (A), 60 min (n = 30) (B), and 90 min (n = 26) (C) classified according to whether they did or did not have CAC on final diagnosis.

View larger version (19K): [in a new window]   FIGURE 4. ROC curves for GBEF measurements at 30 min (A), 60 min (B), and 90 min (C) with best cutoffs identified for each of 3 measures. Difference in area under ROC curve between 30- and 60-min GBEF was statistically significant (P = 0.04). However, differences between 30- and 90-min and 60- and 90-min areas under ROC curves were not statistically significant (P = 0.4 and P = 0.5, respectively).