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Dynamic ¹³N-Ammonia PET: A New Imaging Method to Diagnose Hypopituitarism

¹ Department of Nuclear Medicine, Guangdong Provincial People’s Hospital, Guangzhou, China
² Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

View larger version (45K): [in a new window]   FIGURE 1. Transaxial planes of pituitary gland on dynamic 13N-ammonia PET (10 s/frame). (A) Pituitary gland (arrow) was visible 10 s after internal carotid artery became evident in healthy volunteer. (B) Pituitary gland was not visible 120 s after internal carotid artery became evident in patient with Sheehan’s syndrome.

View larger version (32K): [in a new window]   FIGURE 2. Transaxial planes of pituitary gland on 13N-ammonia PET images 6 min after injection. (A) Pituitary gland was clearly evident in healthy volunteer. (B) Pituitary gland was smaller, and uptake of 13N-ammonia significantly decreased, in patient with Sheehan’s syndrome.

View larger version (14K): [in a new window]   FIGURE 3. Time-activity curves, obtained from dynamic 13N-ammonia PET, for pituitary gland and internal carotid artery of healthy volunteer (A) and patient with hypopituitarism (B).