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Adenosine A1 Receptor Mapping of the Human Brain by PET with 8-Dicyclopropylmethyl-1-11C-Methyl-3-Propylxanthine

Nobuyoshi Fukumitsu, MD1,2, Kenji Ishii, MD1, Yuichi Kimura, PhD1, Keiichi Oda, PhD1, Toru Sasaki, PhD1, Yutaka Mori, MD, PhD3 and Kiichi Ishiwata, PhD1

1 Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
2 Proton Medical Research Center, University of Tsukuba, Ibaragi, Japan
3 Department of Radiology, Jikei University School of Medicine, Tokyo, Japan



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  		FIGURE 1. Chemical structure of 11C-MPDX.

 


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  		FIGURE 2. Time-activity curves in blood and plasma after injection of 11C-MPDX. Data represent means of 5 subjects. SUVs of blood and plasma decreased rapidly for first 10 min after injection. SUV of blood was slightly higher than that of plasma.

 


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  		FIGURE 3. Time-activity curves in each region in brain after injection of 11C-MPDX. Data represent means of 5 subjects. Uptake of 11C-MPDX in each region was high, followed by rapid decrease for first 15 min. SUV was relatively high in striatum and thalamus and low in cerebellum.

 


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  		FIGURE 4. Brain MRI and PET parametric images in typical case. (Top) MRI. (Middle) Distribution image (DV) of 11C-MPDX. (Bottom) rCBF with 15O-H2O. DV of 11C-MPDX was low in cerebellum and high in striatum and thalamus, where rCBF was relatively lower.

 


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  		FIGURE 5. Graphical analysis of 11C-MPDX in frontal cortex, striatum, and cerebellum using Logan plot in 1 case. (•), Data used for linear regression analysis. Slopes of fits represent DVs. C = activity in tissue; Cp(t) = activity in plasma; t = elapsed time.

 




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