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¹⁸F-FDG PET for Detecting Myocardial Viability: Validation of 3D Data Acquisition

¹ Institute of Molecular Biophysics, Radiopharmacy and Nuclear Medicine, Heart and Diabetes Center, Bad Oeynhausen, Germany
² Department of Nuclear Medicine, University of Dresden, Dresden, Germany
³ Department of Nuclear Medicine, Derriford Hospital, Plymouth, United Kingdom
⁴ Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center, Bad Oeynhausen, Germany

View larger version (16K): [in a new window]   FIGURE 1. Absolute activity concentration (Bq/mL) measured in each segment with 2D-G (A), 3D-10 (B), and 3D-5 (C) protocols, compared with 2D-NG acquisition. Each dot represents 1 segment, and a different color represents each of the 21 patients. Corresponding residual plots are in left upper corners. Values for slope of curve and Pearson correlation coefficient were, respectively, 1.04 and 0.98 for 2D-G, 0.97 and 0.97 for 3D-10, and 0.97 and 0.96 for 3D-5.

View larger version (12K): [in a new window]   FIGURE 2. Relative activity concentration in each segment with 2D-G (A), 3D-10 (B), and 3D-5 (C) protocols, compared with 2D-NG acquisition. Segment with maximum absolute activity concentration in each patient equals 100%. Each dot represents 1 segment, and a different color represents each of the 20 patients. One patient with hibernating myocardium confirmed by 13NH3 PET was excluded.

View larger version (61K): [in a new window]   FIGURE 3. Regional variation of absolute activity concentration in each of 20 segments measured with 2D-NG, 2D-G, 3D-10, and 3D-5 protocols. Polar maps are shown for each protocol, and absolute activity concentrations (Bq/mL) have been plotted for each segment. Two representative patients (A and B) are shown.

View larger version (11K): [in a new window]   FIGURE 4. Mean regional activity distribution in all 20 segments measured with 2D-G (A), 3D-10 (B), and 3D-5 (C) protocols, expressed as a ratio to 2D-NG values.

View larger version (10K): [in a new window]   FIGURE 5. (A) Comparison of LVEF measured with 2D-G, 3D-10, and 3D-5 protocols. (B) Corresponding Bland–Altman plot. Slope of curve, {2D,3D} intercept, and Pearson correlation coefficient were 1.02, {0.4,-0.4}, and 0.96, respectively, for 3D-10 and 0.91, {-1.3,1.2}, and 0.96, respectively, for 3D-5.