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¹⁸F-FDG Kinetics and Gene Expression in Giant Cell Tumors

¹ Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
² Institute of Immunology, University Rostock, Rostock, Germany
³ Department I, University Orthopedic Clinic, Heidelberg, Germany

View larger version (88K): [in a new window]   FIGURE 1. Gene chip data for 5 giant cell tumors. Normalized expression values are presented in descending order. Data are sorted according to median gene expression values for 5 tumor specimens. Three of the genes with high expression values are shown in bold type (small proteoglycan I, Wilms’ tumor-related protein, and RhoA). Cluster analysis was applied to the data and revealed 2 subgroups, consisting of 2 tumors (left 2 columns) and 3 tumors (right 3 columns).

View larger version (11K): [in a new window]   FIGURE 2. (A) Correlation of SUV with VEGF-A expression (r = 0.9618; P = 0.0089). (B) Correlation of SUV with Cdc2 expression (r = 0.9392; P = 0.0178).

View larger version (9K): [in a new window]   FIGURE 3. (A) Correlation of vessel density (VB) with VEGF-B (r = 0.8716; P = 0.0541). (B) Correlation of vessel density (VB) with cyclin E (r = 0.9885; P = 0.0015).

View larger version (10K): [in a new window]   FIGURE 4. (A) Correlation of k3 with sFLT (r = 0.9444; P = 0.0156). (B) Correlation of k3 with HIF-1 (r = 0.9738; P = 0.0051).

View larger version (9K): [in a new window]   FIGURE 5. Correlation of fractal dimension (FD) with VEGF-A (r = 0.9707; P = 0.0060).

View larger version (21K): [in a new window]   FIGURE 6. Comparison of 2 giant cell tumors with low 18F-FDG uptake and high 18F-FDG uptake. Both images are scaled to the same range (SUV, 0–5.8). (Upper image) Giant cell tumor of right tibia with an 18F-FDG SUV of 2.4. The relative expression value for VEGF-A was 81. (Lower image) Giant cell tumor of left tibia with an 18F-FDG SUV of 5.8. The relative expression value for VEGF-A was 240.