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Ursodeoxycholic Acid–Augmented Hepatobiliary Scintigraphy in the Evaluation of Neonatal Jaundice

¹ Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
² Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

View larger version (85K): [in a new window]   FIGURE 1. 99mTc-Mebrofenin scintigraphy of 45-d-old infant with neonatal jaundice before (A) and after (B) UDCA premedication. Drainage of tracer into the intestine (arrow) is seen on the post-UDCA study at 5 h and later. ant = anterior; post = posterior.

View larger version (63K): [in a new window]   FIGURE 2. (A) Pre-UDCA 99mTc-mebrofenin hepatobiliary scintigraphy of 2-mo-old infant shows no detectable intestinal clearance of tracer up to 24 h. (B) Post-UDCA study shows intestinal clearance (arrow) by 3 h, which increases at 5 and 24 h. ant = anterior; post = posterior.

View larger version (53K): [in a new window]   FIGURE 3. (A) In a 40-d-old infant with severe hepatic dysfunction, pre-UDCA 99mTc-mebrofenin study shows high background activity, with no detectable tracer clearance into the intestine. (B) Post-UDCA study of same infant shows tracer draining into the intestine (arrow) by 1 h. ant = anterior.