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Brain Incorporation of 11C-Arachidonic Acid, Blood Volume, and Blood Flow in Healthy Aging: A Study With Partial-Volume Correction

Giampiero Giovacchini, MD, PhD1,2, Alicja Lerner, MD3, Maria T. Toczek, MD4, Charles Fraser, MS5, Kaizong Ma, MS1, James C. DeMar, PhD1, Peter Herscovitch, MD5, William C. Eckelman, PhD5, Stanley I. Rapoport, MD1 and Richard E. Carson, PhD5

1 Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland
2 Postgraduate Specialty School in Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
3 Human Motor Control Section, National Institute on Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland
4 Clinical Epilepsy Section, National Institute on Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland
5 PET Department, Clinical Center, National Institutes of Health, Bethesda, Maryland



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  		FIGURE 1. Estimation of white matter activity for 3S-PVC (Eq. 2) from a 11C-AA PET frame (25–30 min after injection). Activity values for pure white matter were obtained from voxels with smoothed white matter mask value (sWM) close to 1.0. Each point represents mean ± SD of activity in voxels plotted vs. smoothed white matter mask. Activity values of voxels with sWM from 0.99 to 1.0 were fitted to straight line and value at sWM = 1.0 was used as white matter value.

 


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  		FIGURE 2. Transverse images derived from 1 typical subject at level of subcortical nuclei (top) and centrum semiovale (bottom). (A) MR image. (B) Original image of incorporation rate for 11C-AA (K*). (C) K* image after 2S-PVC. (D) K* image after 3S-PVC. K* images are scaled to maximum of 12 µL/min/mL.

 


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  		FIGURE 3. Relationship between CBF and 11C-AA incorporation rate (K*) before PVC ({square}), after 2S-PVC ({triangleup}), and after 3S-PVC ({circ}). Each point represents global gray matter value for 1 subject (n = 15). No significant relation between K* and CBF was detected. Regression equations were as follows: Uncorrected, K* = 2.93 + 0.039 CBF (r = 0.26; P > 0.05); 2S, K* = 1.65 + 0.075 CBF (r = 0.45; P > 0.05); 3S, K* = 3.98 + 0.047 CBF (r = 0.30; P > 0.05).

 




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