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PET for Evaluation of Differential Myocardial Perfusion Dynamics After VEGF Gene Therapy and Laser Therapy in End-Stage Coronary Artery Disease

René A. Tio, MD, PhD1, Eng S. Tan, MD1, Gillian A.J. Jessurun, MD, PhD1, Nic Veeger2, Pieter L. Jager, MD, PhD3, Riemer H.J.A. Slart, MD3, Richard M. de Jong, MD, PhD1, Jan Pruim, MD, PhD4, Geke A.P. Hospers, MD, PhD5, Antoon T.M. Willemsen, PhD4, Mike J.L. de Jongste, MD, PhD1, Ad J. van Boven, MD, PhD1, Dirk J. van Veldhuisen, MD, PhD1 and Felix Zijlstra, MD, PhD1

1 Department of Cardiology, University Hospital Groningen, Groningen, The Netherlands
2 Trial Coordination Center, University Hospital Groningen, Groningen, The Netherlands
3 Department of Nuclear Medicine, University Hospital Groningen, Groningen, The Netherlands
4 PET Center, University Hospital Groningen, Groningen, The Netherlands
5 Department of Medical Oncology, University Hospital Groningen, Groningen, The Netherlands



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FIGURE 1. (A) Static image of long-axis views of NH3 PET scan at rest (left) and during dipyridamole stress (right). Top 2 panels, at baseline; bottom 2 panels, at follow-up. (B) Polar map reconstruction of scans shown in A: VEGF-treated patient showing marked improvement in perfusion and reduction of anginal complaints. Top 2 panels, at baseline; bottom 2 panels, at follow-up; left-hand panels, rest; right-hand panels, dipyridamole stress. (C) Polar map of DMR patient showing no improvement in perfusion images or in anginal complaints. Top 2 panels, at baseline; bottom 2 panels, at follow-up; left-hand panels, rest; right-hand panels, dipyridamole stress.

 


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FIGURE 2. (A) CCS angina pectoris classification at baseline and after 3 mo of follow-up in 3 groups (control, standard therapy; DMR, laser treatment; VEGF, VGEF gene therapy). Changes were significantly different between the 3 groups (P < 0.001). (B) Change in CCS class in 3 individual groups. Change in VEGF gene therapy group was significantly different from that of other 2 groups (P < 0.05).

 





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