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Comparative 18F-FDG PET of Experimental Staphylococcus aureus Osteomyelitis and Normal Bone Healing

Jyri K. Koort, MD1, Tatu J. Mäkinen, MD1, Juhani Knuuti, MD, PhD2, Jari Jalava, PhD3 and Hannu T. Aro, MD, PhD1

1 Orthopaedic Research Unit, Department of Surgery, University of Turku, Turku, Finland
2 Turku PET Centre, University of Turku, Turku, Finland
3 Department of Human Microbial Ecology and Inflammation, National Public Health Institute, Turku, Finland



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  		FIGURE 1. Sequential 18F-FDG PET images of rabbit tibias at 3 and 6 wk (top and bottom, respectively). In the control animal (left), the healing-bone region shows a marked decrease in 18F-FDG activity by 6 wk (SUV ratios, 1.9 and 1.2 at 3 and 6 wk, respectively). In the experimental animal (right), the corresponding bone region with osteomyelitis shows continuous 18F-FDG uptake (SUV ratios, 3.1 and 5.5 at 3 and 6 wk, respectively).

 


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  		FIGURE 2. Sequential pQCT images of rabbit tibias at 3 and 6 wk (top and bottom, respectively). In the control animal (left), closure of the cortical window is already seen at 3 wk. In the experimental animal, with an osteomyelitic bone (right), no apparent closure of the cortical window is seen at 3 wk and the cortical window is still open at 6 wk.

 


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  		FIGURE 3. Plain radiographs demonstrating a healing defect (arrow) of the proximal tibia in a control animal (left) and a localized osteomyelitic defect (arrows) in an experimental animal (right).

 


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  		FIGURE 4. 18F-FDG activity in intact bones, healing bone defects, and osteomyelitic regions. SUV ratios were calculated between operated and nonoperated sides.

 




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