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Absolute Quantification of Regional Cerebral Glucose Utilization in Mice by 18F-FDG Small Animal PET Scanning and 2-14C-DG Autoradiography

Hiroshi Toyama, MD, PhD1, Masanori Ichise, MD1, Jeih-San Liow, PhD1, Kendra J. Modell, BS1, Douglass C. Vines, BS, CNMT1, Takanori Esaki, MD2, Michelle Cook, BS2, Jurgen Seidel, PhD3, Louis Sokoloff, MD2, Michael V. Green, MS3 and Robert B. Innis, MD, PhD1

1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
2 Laboratory of Cerebral Metabolism, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
3 Department of Nuclear Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland



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  		FIGURE 1. Representative coronal 18F-FDG PET and 2-14C-DG autoradiographic images of brain sections of unanesthetized mouse with ROIs delineated on them. Fr = frontal cortex; Pa = parietal cortex; Te = temporal cortex; Oc = occipital cortex.

 


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  		FIGURE 2. Representative time–activity curves of 18F-FDG and 2-14C-DG in unanesthetized mouse.

 


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  		FIGURE 3. Comparison of weighted-average rCMRglc (µmol/100 g/min) determined by 18F-FDG small animal PET and 2-14C-DG autoradiography in cortical ROIs of normoglycemic, awake and isoflurane anesthetized mice.

 


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  		FIGURE 4. Comparison of weighted-average cortical rCMRglc (µmol/100 g/min) determined by 2-14C-DG autoradiography (A) and 18F-FDG PET (B) and of 18F-FDG uptake (%ID/g) (C) in mice under isoflurane or ketamine/xylazine anesthesia and awake mice.

 




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