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Perfusable Tissue Index as a Potential Marker of Fibrosis in Patients with Idiopathic Dilated Cardiomyopathy

Paul Knaapen, MD1, Ronald Boellaard, PhD2, Marco J.W. Götte, MD, PhD1, Pieter A. Dijkmans, MD1, Linda M.C. van Campen, MD1, Carel C. de Cock, MD, PhD1, Gert Luurtsema, BSc2, Cees A. Visser, MD, PhD1, Adriaan A. Lammertsma, PhD2 and Frans C. Visser, MD, PhD1

1 Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
2 PET Center, VU University Medical Center, Amsterdam, The Netherlands



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  		FIGURE 1. Short-axis ATF (A) and PTF (B) images of a healthy volunteer. Arrow in PTF image indicates inferior wall. Spillover effects from adjacent liver tissue are present.

 


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  		FIGURE 2. PTI for healthy control subjects and DCM patients.

 


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  		FIGURE 3. ATF (A) and PTF (B) for healthy control subjects and DCM patients.

 


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  		FIGURE 4. Frequency distributions (percentage of left ventricle) of normalized MBF (A) and PTI (B) for both healthy control subjects (solid lines) and DCM patients (dashed lines). COVs were increased for MBF and PTI in DCM patients compared with COVs for control subjects, indicating increased heterogeneity (P < 0.05).

 




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