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18F-FDG Accumulation in Atherosclerotic Plaques: Immunohistochemical and PET Imaging Study

Mikako Ogawa, MS1,2, Seigo Ishino, BS3, Takahiro Mukai, PhD4, Daigo Asano, BS3, Noboru Teramoto, BS1, Hiroshi Watabe, PhD1, Nobuyuki Kudomi, PhD1, Masashi Shiomi, PhD5, Yasuhiro Magata, PhD2, Hidehiro Iida, PhD1 and Hideo Saji, PhD3

1 Department of Investigative Radiology, Research Institute, National Cardiovascular Center, Suita, Japan
2 Laboratory of Genome Bio-Photonics, Photon Medical Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan
3 Department of Pathofunctional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
4 Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University, Kyoto, Japan
5 Institute for Experimental Animals, Kobe University School of Medicine, Kobe, Japan



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  		FIGURE 1. Photomicrographs of atherosclerotic lesions in thoracic aortas of control (A and B) and WHHL (C and D) rabbits. Azan-Mallory staining (A and C) and immunohistochemical staining with antimacrophage monoclonal antibody RAM-11 (B and D) are shown. Panel E is a magnified view of the area boxed in panel D. Macrophages can be seen (arrowheads) in serial sections from WHHL rabbits (C and D). Bars = 200 µm.

 


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  		FIGURE 2. Correlation between 18F-FDG uptake and macrophage number in aortic segments (n = 86) (A) or between 18F-FDG uptake and the ratio of the area of the intima to the area of the whole cross section in aortic segments (n = 86) (B) from WHHL rabbits.

 


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  		FIGURE 3. PET images (A and D), CT images (B and E), and superimposed PET/CT images (C and F) in the sagittal (I) and coronal (II) planes for WHHL (A, B, and C) and control (D, E, and F) rabbits. Orange arrows, orange arrowheads, and white arrowheads indicate aortas, kidneys, and livers, respectively.

 




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