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Imaging Apoptosis with 99mTc-Annexin-V in Experimental Subacute Myocarditis

Can Peker, MD1, Laure Sarda-Mantel, MD1, Paule Loiseau1, François Rouzet, MD1, Lubna Nazneen1, Geneviève Martet1, Jean-Marc Vrigneaud, PhD1, Alain Meulemans, PhD1, Georges Saumon, MD1, Jean-Baptiste Michel, MD, PhD2 and Dominique Le Guludec, MD, PhD1

1 Équipe d’Accueil 35 12, Faculté Bichat-Claude Bernard et Service de Médecine Nucléaire de l’hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France
2 Institut National de la Santé et de la Recherche Médicale, Unité 460, Unité de Formation et de Recherche Bichat, Paris, France



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  		FIGURE 1. Scintigrams and autoradiographic images obtained with ANX in a WBN/Kob rat (A) and a control rat (B) 4 h after 99mTc-ANX injection. Greater tracer activity is seen in the cardiac area of the WBN/Kob rat than in the control rat on planar anterior views, corresponding to increased diffuse myocardial uptake on the autoradiogram of transaxial cardiac sections.

 


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  		FIGURE 2. Comparative histograms of WBN/Kob and control rats: HLR on 4-h scintigrams (A), ANX uptake on myocardial autoradiograms (B), and percentage of Apostain-positive myocardial cells on 5-µm myocardial sections (C). The error bars represent SEM.

 


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  		FIGURE 3. (A) Hematoxylin–eosin and Apostain staining of transverse heart sections. No positive staining is seen with Apostain in the control heart (left), whereas typical Apostain-positive brownish nuclei are observed in the heart of the WBN/Kob rat (right). (B) Negative anti-CD4 and anti-CD8 immunostaining in transverse sections of a control heart (left), and positive anti-CD4 and anti-CD8 pink immunostaining in transverse sections of the heart of a WBN/Kob rat (right).

 




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