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^99mTc-Labeled Antimicrobial Peptide Ubiquicidin (29-41) Accumulates Less in Escherichia coli Infection than in Staphlococcus aureus Infection

Punjab Institute of Nuclear Medicine, Faisalabad, Pakistan

View larger version (31K): [in a new window]   FIGURE 1. Scintigraphically determined biodistribution of UBI (29-41) in rabbits. %ID/organ = percentage injected dose per organ.

View larger version (48K): [in a new window]   FIGURE 2. Biodistribution of 99mTc-UBI (29-41) in rabbit at 30 min after injection. Liver (solid arrow), kidney (dashed arrow), and urinary bladder (ball arrow) are well outlined.

View larger version (65K): [in a new window]   FIGURE 3. 99mTc-UBI (29-41) scintigram of rabbit with S. aureus thigh muscle infection (arrow).

View larger version (56K): [in a new window]   FIGURE 4. 99mTc-UBI (29-41) scintigram of rabbit with E. coli thigh muscle infection (arrow).

View larger version (50K): [in a new window]   FIGURE 5. 99mTc-UBI (29-41) scintigram of rabbit with turpentine oil–induced thigh muscle inflammation (arrow).

View larger version (36K): [in a new window]   FIGURE 6. Accumulation of 99mTc-UBI (29-41) in rabbits with infected/inflamed thigh muscle. More accumulation is evident in the S. aureus group than in the E. coli group. Minimum uptake of tracer is noted in turpentine oil and killed S. aureus inflammatory groups.