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Accuracy of a Method Using Short Inhalation of ¹⁵O-O₂ for Measuring Cerebral Oxygen Extraction Fraction with PET in Healthy Humans

¹ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California
² Brain Injury Research Center, UCLA Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California
³ UCLA-DOE Center for Molecular Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California

View larger version (70K): [in a new window]   FIGURE 1. Example of parametric images. Parametric images of CBV (top left) and CBF (top right) were used to generate OEF image (bottom left). Parametric image for CMRO2 (bottom right) was generated by applying the following formula to each pixel: CMRO2 = CaO2 x OEF x CBF.

View larger version (15K): [in a new window]   FIGURE 2. (A) Agreement of OEFpet and OEFav. The cross-line indicates the mean value for OEFpet and OEFav. (B) Bland-Altman plot of the same data.