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Uptake of [¹¹¹In-DTPA⁰]Octreotide in the Rat Kidney Is Inhibited by Colchicine and Not by Fructose

Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands

View larger version (20K): [in a new window]   FIGURE 1. Effects of D-lysine (400 mg/kg), fructose (2 and 20 mmol/kg) and the combination of 400 mg of D-lysine per kilogram plus 20 mmol of fructose per kilogram on kidney radioactivity 24 h after injection of [111In-DTPA0]octreotide. Groups consist of 3 rats. *P < 0.01 versus control.

View larger version (17K): [in a new window]   FIGURE 2. Effects of different treatment modalities with colchicine on kidney radioactivity 24 h after injection of [111In-DTPA0]octreotide. Groups consist of 6–9 rats. Table 1 describes the experimental groups and gives their abbreviations. Probability values are as follows: (a) P < 0.001 vs. control; (b) P = not statistically significant (NS) vs. control; (c) P < 0.01 vs. control, and P < 0.001 vs. 1 mg of colchicine per kilogram; (d) P < 0.001 vs. control, and P = NS vs. 400 mg of D-lysine per kilogram; (e) P < 0.001 versus control, and P = NS vs. 1 mg of colchicine per kilogram; (f) P < 0.001 vs. control, and P < 0.001 vs. 1 mg of colchicine per kilogram.

View larger version (18K): [in a new window]   FIGURE 3. Effects of D-lysine (400 mg/kg) and 2 combinations of colchicine with D-lysine on kidney radioactivity 24 h after injection of [111In-DTPA0]octreotide. Groups consist of 6–9 rats. Table 1 describes the experimental groups and gives their abbreviations. *P < 0.001 vs. control; P < 0.01 vs. 400 mg of D-lysine per kilogram; P = NS vs. 400 mg of lysine per kilogram.