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The Radiotoxicity of ¹³¹I Therapy of Thyroid Cancer: Assessment by Micronucleus Assay of B Lymphocytes

¹ Department of Radiology, Toyama Medical and Pharmaceutical University, Toyama, Japan
² Department of Pediatrics, Toyama Medical and Pharmaceutical University, Toyama, Japan
³ Department of Nuclear Medicine, Kanazawa University, Kanazawa, Japan
⁴ Department of Radiology, Asahikawa Medical University, Asahikawa, Japan
⁵ Department of Clinical Infectious Diseases, Toyama Medical and Pharmaceutical University, Toyama, Japan

View larger version (33K): [in a new window]   FIGURE 1. Photomicrographs of binucleated cells, including one without (A) and one with (B) a micronucleus (M).

View larger version (40K): [in a new window]   FIGURE 2. The frequency of micronuclei among peripheral lymphocytes and B lymphocytes before and after 131I therapy.

View larger version (19K): [in a new window]   FIGURE 3. The increased number of micronuclei among peripheral lymphocytes and B lymphocytes.