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PET and SPECT for Detection of Tumor Progression in Irradiated Low-Grade Astrocytoma: A Receiver-Operating-Characteristic Analysis

Marcus Henze, MD1,2, Ashour Mohammed, PhD1, Heinz P. Schlemmer, MD3, Klaus K. Herfarth, MD4, Simone Hoffner, MD1,2, Sabine Haufe, MD1, Walter Mier, PhD1, Michael Eisenhut, PhD5, Jürgen Debus, MD, PhD4 and Uwe Haberkorn, MD1,2

1 Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
2 Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
3 Department of Diagnostic Radiology, Eberhard-Karls University, Tübingen, Germany
4 Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
5 Division of Radiochemistry and Radiopharmacology, German Cancer Research Center, Heidelberg, Germany



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FIGURE 1. L/n ratios (mean ± SD) for 123I-IMT, 18F-FDG, and 99mTc-MIBI. In contrast to 99mTc-MIBI, both 123I-IMT and 18F-FDG allow highly significant differentiation between PT and nPT groups.

 


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FIGURE 2. ROC curves for 123I-IMT, 18F-FDG, and 99mTc-MIBI.

 





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