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Gated Myocardial SPECT to Predict Response to ß-Blocker Therapy in Patients with Idiopathic Dilated Cardiomyopathy

Kazuki Fukuchi, MD1, Yoshio Yasumura, MD2, Keisuke Kiso, MD1,3, Kohei Hayashida, MD1, Kunio Miyatake, MD2 and Yoshio Ishida, MD1

1 Department of Radiology, National Cardiovascular Center, Suita, Osaka, Japan
2 Division of Cardiology, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
3 Department of Cardiology, Saka General Hospital, Shiogama, Miyagi, Japan



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FIGURE 1. Assessment of LV shape using the sphericity index of gated SPECT. Bold lines represent tracing of LV contours using quantitative gated SPECT algorithm on end-diastolic images. Lines with arrowheads represent measurements of the long and vertical axes of the left ventricle. L = long axis of left ventricle; V = vertical axis of left ventricle.

 


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FIGURE 2. Representative gated SPECT images from good responders (A) and poor responders (B). Shown are ungated perfusion polar maps before therapy (left panels) and serial 3-dimensional displays of end-diastolic (grid) and end-systolic (solid) surfaces from a right anterior oblique 30° view (middle and right panels). Small perfusion defects are present in apical and posterior myocardium of good responders (extent of defect, 4%). Three-dimensional displays show that LV shape is preserved as a prolate ellipse (sphericity index, 1.7). LVEF increased by 33% after ß-blocker therapy. In contrast, multiple perfusion defects were observed in poor responders (extent of defect, 11%) and the LV cavity is spheric (sphericity index, 1.3). LVEF increased by only 6% after 4 mo of ß-blocker therapy.

 





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