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Dynamic Imaging of Striatal D₂ Receptors in Mice Using Quad-HIDAC PET

Center for Radiopharmaceutical Science, Paul Scherrer Institute, Villigen, Switzerland

View larger version (89K): [in a new window]   FIGURE 1. (A) Series of coronal sections (ventral to dorsal; slice thickness, 0.3 mm) through the striatum of a mouse injected with 18F-fallypride. The images were obtained by reconstructing data from 20 to 60 min after injection. (B) Representative example of time-activity curves in the striatum () and the cerebellum () for a 150-min PET experiment. (C) Coronal view of a paramatric Rv image with maximum Rv values of 14 in the striatum (st). Lower values were found in brain regions possibly representing the thalamus (th) and olfactory bulb (bu).

View larger version (16K): [in a new window]   FIGURE 2. Estimation of the BP as a function of scan duration for a PET experiment with 150-min scanning time. The BP in the right striatum (, ) and the left striatum (, ) was calculated by 2 different kinetic modeling approaches, the Lammertsma simplified reference tissue model (BPRf; , ) and the Ichise method (Rv; , ).

View larger version (12K): [in a new window]   FIGURE 3. Time-activity curves in the striatum (, •, ) and cerebellum (, , ) of 3 PET scans performed in a single baseline animal. Curves were normalized to the injected dose per body weight and are expressed as SUV.

View larger version (21K): [in a new window]   FIGURE 4. (A) Normalized striatal time-activity curves under baseline (, •, ) and blocking (, , ) conditions in 3 animals each. Curves were normalized to the injected dose per body weight and are expressed as SUV. (B) Corresponding coronal slices through the striatum of a baseline (left) and a haloperidol-treated (right) animal. Images were obtained by adding data from 20 to 60 min after injection.