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Accurate Dose Calibrator Activity Measurement of 90Y-Ibritumomab Tiuxetan

Jeffry A. Siegel, PhD1, Brian E. Zimmerman, PhD2, Kory Kodimer, PhD3, Mary A. Dell, MS4 and William E. Simon, MS5

1 Nuclear Physics Enterprises, Wellington, Florida
2 National Institute of Standards and Technology, Gaithersburg, Maryland
3 Cardinal Health Nuclear Pharmacy Services, Woodland Hills, California
4 Capintec, Inc., Ramsey, New Jersey
5 Sun Nuclear Corp., Melbourne, Florida



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  		FIGURE 1. Correction factor (CF) as function of volume normalized to 6 mL, determined by site 1 based on measurements obtained on 1 CRC dose calibrator. Volume dependence is 0.28%/mL.

 


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  		FIGURE 2. Correction factor (CF) as function of volume normalized to 6 mL, determined by site 2 based on measurements obtained on 3 CRC (•) and 1 Atomlab ({diamondsuit}) dose calibrators. Volume dependence is 0.21%/mL and 0.16%/mL, respectively.

 


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  		FIGURE 3. Correction factor (CF) as function of volume normalized to 6 mL, determined by site 3 based on average of measurements obtained on 3 CRC dose calibrators. Bold line ({diamondsuit}) represents results for sequential 1-mL volume withdrawal from 9 to 3 mL, and dashed line (•) represents results for sequential 1-mL volume addition from 3 to 9 mL. Volume dependence is 0.20%/mL and 0.11%/mL, respectively.

 


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  		FIGURE 4. Correction factor (CF) as function of volume normalized to 6 mL, determined by sites 4 (•) and 5 ({blacksquare}) based on average of measurements obtained on 3 Mark V and 15 Atomlab dose calibrators, respectively. Volume dependence is 0.12%/mL and 0.13%/mL, respectively.

 




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