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PET-Measured Responses of MBF to Cold Pressor Testing Correlate with Indices of Coronary Vasomotion on Quantitative Coronary Angiography

Thomas H. Schindler, MD1,2, Egbert U. Nitzsche, MD2, Manfred Olschewski, MSc3, Ingo Brink, MD2, Michael Mix, MSc, PhD2, John Prior, MD, PhD1, Alvaro Facta, MD1, Massayuki Inubushi, MD, PhD1, Hanjoerg Just, MD2 and Heinrich R. Schelbert, MD, PhD1

1 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California
2 Division of Cardiology and Nuclear Medicine, Medical Clinic III, University Hospital of Albert Ludwigs University, Freiburg, Germany
3 Department of Medical Statistics and Biometry, Albert Ludwigs University, Freiburg, Germany



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  		FIGURE 1. Study protocol. (A) Study inclusion at coronary angiography and quantitative assessment of epicardial vasoreactivity during CPT. a = angiogram. (B) Within 20 d of study inclusion MBF assessment with PET at rest and during CPT.

 


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  		FIGURE 2. (A) Normal coronary angiogram of the left coronary tree in the RAO view of a control patient. (B) Corresponding coronary angiogram during sympathetic activation by CPT. (C and D) Quantitative coronary angiographic evaluation of the proximal-mid LAD segment at rest (mean diameter, 2.0 mm) (C) and during CPT (mean diameter, 2.5 mm) (D).

 


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  		FIGURE 3. (A) Normal coronary angiogram of the left coronary artery tree in the LAO view in a chronic smoker at baseline. (B) Corresponding coronary angiogram during sympathetic activation by CPT. (C and D) Quantitative coronary angiographic evaluation of the proximal-mid LAD segment at rest (mean diameter, 1.89 mm) (C) and during CPT (mean diameter, 1.57 mm) (D).

 


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  		FIGURE 4. Correlation of CPT-induced change in RPP and epicardial LA in normal control patients ({circ}) and in the group at risk for CAD (•), demonstrating a significant correlation in normal patients but no relation for patients at risk for CAD.

 


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  		FIGURE 5. Correlation of CPT-induced change in RPP and regional MBF in normal control patients ({circ}) and in the group at risk for CAD (•), revealing a significant correlation in normal patients but no relation for patients at risk for CAD.

 


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  		FIGURE 6. Percent change of CVR in the control group and in patients at risk for CAD.

 


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  		FIGURE 7. Percent change of epicardial LA and MBF to CPT of the study population.

 




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