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Application of MRI-Based Partial-Volume Correction to the Analysis of PET Images of µ-Opioid Receptors Using Statistical Parametric Mapping

¹ Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland
² Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland
³ Department of Neuroscience, The Johns Hopkins Medical Institutions, Baltimore, Maryland

View larger version (46K): [in a new window]   FIGURE 1. Age-associated increase in regional brain µ-OR binding in the left temporal cortex after PVC. Before PVC, regional brain µ-OR binding did not significantly increase with age. The bracket on the left shows brain regions included in the PET axial field of view.

View larger version (14K): [in a new window]   FIGURE 2. A plot of the temporal cluster µ-OR binding values for the PVC data and a similar location in non-PVC data shows a steeper age regression line and less residual variability for the PVC data (•) than for the non-PVC data ().