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Comparison of O-(2-18F-Fluoroethyl)-L-Tyrosine PET and 3-123I-Iodo-{alpha}-Methyl-L-Tyrosine SPECT in Brain Tumors

Dirk Pauleit, MD1,2, Frank Floeth, MD3, Lutz Tellmann, BSc4, Kurt Hamacher, PhD5, Hubertus Hautzel, MD1,2, Hans-W. Müller, MD2, Heinz H. Coenen, PhD5 and Karl-J. Langen, MD4

1 Clinic for Nuclear Medicine, Research Center Jülich, Jülich, Germany
2 Department of Nuclear Medicine, Heinrich-Heine-University, Düsseldorf, Germany
3 Department of Neurosurgery, Heinrich-Heine-University, Düsseldorf, Germany
4 Institute of Medicine, Research Center Jülich, Jülich, Germany
5 Institute of Nuclear Chemistry, Research Center Jülich, Jülich, Germany



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  		FIGURE 1. Comparison of TBRs for 18F-FET PET and 123I-IMT SPECT demonstrated a highly significant correlation (r = 0.96; P < 0.001).

 


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  		FIGURE 2. Coregistered 18F-FET PET, 123I-IMT SPECT, and MRI of 56-y-old woman with a malignant oligodendroglioma (patient 14) in the right frontal lobe. The tumor was clearly identified on 18F-FET PET and 123I-IMT SPECT and was rated as definitely present by all 3 observers. The TBR was 3.4 for 18F-FET PET scans and was 2.2 for 123I-IMT SPECT scans. On PET images, the accumulation of 18F-FET was higher in the superior sagittal sinus (arrowhead) and in the temporal muscle (arrows) compared with that on the 123I-IMT SPECT images. (A) 18F-FET PET. (B) MRI. (C) 123I-IMT SPECT.

 


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  		FIGURE 3. Coregistered 18F-FET PET, 123I-IMT SPECT, and MRI of 57-y-old woman with a low-grade astrocytoma (patient 11) in the posterior cingulum. The tumor was identified on 18F-FET PET but not on the 123I-IMT SPECT images by the 3 observers. The TBR was 1.8 for 18F-FET PET and was 1.1 for 123I-IMT SPECT. (A) 18F-FET PET. (B) MRI. (C) 123I-IMT SPECT.

 




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