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Uptake of ¹¹¹In-Z2D3 on SPECT Imaging in a Swine Model of Coronary Stent Restenosis Correlated with Cell Proliferation

¹ Division of Cardiology, Department of Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island
² Armed Forces Institute of Pathology, Washington, D.C.
³ Northeastern University, Boston, Massachusetts

View larger version (26K): [in a new window]   FIGURE 1. Bar graph showing BrdU proliferative (prolif) indices for scan-positive and scan-negative vessels for the adventitia (Adv), media (Med), and neointima (Neo). fx = fracture.

View larger version (19K): [in a new window]   FIGURE 2. Plot of vessel count ratio (stented-to-control) versus proliferative index (percentage of proliferating cells of total cells per field). = points plotted for scan-negative experiments; • = points plotted for scan-positive experiments.

View larger version (68K): [in a new window]   FIGURE 3. (A) Transverse, coronal, and sagittal planes with arrows indicating focal tracer uptake localized to the distal LAD. (B) Upper panels—low-power images in Movat pentachrome stain—show stent artifacts and focal areas of neointimal growth. Lower panels, in high power, show actin-positive cytoplasm (brown-red) on the left and BrdU-positive nuclei (brown-red) on the right.

View larger version (68K): [in a new window]   FIGURE 4. (A) Same experiment as in Figure 3: transverse, coronal, and sagittal planes with arrows indicating focal tracer uptake localized to the mid RCA. (B) Upper panels—low-power images in Movat pentachrome stain—show stent artifacts and focal areas of neointimal growth. Lower panels, in high power, show actin-positive cytoplasm (brown-red) on the left and BrdU-positive nuclei (brown-red) on the right.

View larger version (54K): [in a new window]   FIGURE 5. (A) Example of scan interpreted as negative for focal antibody uptake in region of coronary arteries. (B) Upper panels—low-power images in Movat pentachrome stain—show stent artifacts and minimal neointimal growth in the LAD. Lower panels, in high power, show very few actin-positive cells on the left and correspondingly few BrdU-positive cells on the right. (C) Upper panels—low-power images in Movat pentachrome stain—show stent artifacts and minimal neointimal growth in the RCA. Lower panels, in high power, show very few actin-positive cells on the left and correspondingly few BrdU-positive cells on the right.